Years before the term “opioid epidemic” became commonplace, Jamie Boyle watched her sister and mother both succumb to an unknown, unnamed illness. As a way to process what was happening, she picked up her camera and started filming. Little did she know her family members had become pawns in a deceptive, pharmaceutical promotion that was transforming the way medicine was practiced, resulting in the deadliest, manmade public health crisis in U.S. history. The intimate footage from Anonymous Sister is captured from inside Boyle’s tight-knit, loving family, revealing an emotional truth that cannot be fully appreciated from news stories and statistics. In trying to understand a nationwide catastrophe of such epic proportion, the most important vantage point might just be from within.